Pharmaceutical Formulations & Drug Delivery

Hydrogels have aƩ racted research aƩ enƟ on for Ɵ ssue engineering, e.g. wound healing and bone regeneraƟ on. ThermosensiƟ ve amphiphilic block copolymers, polyethylene oxide-polypropylene oxide copolymers (Poloxamers or Pluronics, PPO-PEO-PPO), thanks to their ability to undergo thermal gelaƟ on, to their good tolerability, and low irritancy/toxicity, have been used in the biomedical fi eld for instance for Ɵ ssue engineering and drug delivery applicaƟ ons [Hyaluronic acid (HA) is naturally occurring glycosaminoglycan, presents in mammalian connecƟ ve Ɵ ssues. It has been demonstrated that

HA promotes dermal regeneraƟ on and for this, it is widely used as dermal fi llers, as wound dressings and substrates for dermal engineering applicaƟ ons It has to be highlighted that infecƟ on is a crucial and generally unsolved issue in wound healing and bone regeneraƟ on. Therefore, materials containing anƟ microbial compounds, such as quaternary ammonium salts, TiO2, and, Ag nanoparƟ cles (Ag NPs) have been uƟ lized. Among these compounds, Ag NPs have shown the capability to inhibit or decline infecƟ ons. Various techniques, including chemical and physical approaches, have been developed to synthesise Ag NPs. Unfortunately, in the aforemenƟ oned approaches, organic passivators, toxic both for the environment and human body, are used. Biosynthesis of NPs, by using microorganisms and plants, has received considerable aƩ enƟ on due to the growing need to develop environmentally and non-toxic technologies. In this context, we propose novel and green nanocomposites injectable hydrogels based on HA, Pluronics and AgNPs for wound healing and bone regeneraƟ on applicaƟ ons.