Rezvan Jamaledin
Federico Secondo University, Italy
Title: Polymer microneedle patches for delivery of fi lamentous bacteriophage displaying the pepÆŸ de OVA257-264 for sÆŸ mulaÆŸ on of innate and adapÆŸ ve immunity
Biography
Biography: Rezvan Jamaledin
Abstract
Biodegradable polymer microneedles are recognized as a valuable route for transdermal drug and vaccine delivery. Biodegradable microneedle technologies have been used for transdermal sustained
deliveries of diff erent drugs and vaccines. Bacteriophages enƟƟ es have aƩ racted growing interest as opƟ mal vaccine delivery vehicles. The use of bacteriophage as an anƟ gen delivery system is based on a modifi caƟ on of the phage display technology. In parƟ cular, it is designed to express the fi lamentous bacteriophage anƟ gen display mulƟ ple copies of exogenous pepƟ des (or polypepƟ des) as fusions to viral capsid proteins. Since dermis is highly populated by dendriƟ c cells, the system as a candidate vaccine
delivery is able to induce both the innate and the adapÆŸ ve response. This work explores the development of controlled release microparÆŸ cles made of poly lacÆŸ c-co-glycolic acid (PLGA) that stably encapsulate phage. The microparÆŸ cles were prepared by double emulsion method. The size of the micro parÆŸ cles is around 15μm. Overall, Phage-encapsulated PLGA promises an outstanding future for the development of diff erent phage-based vaccine plaÆž orms.