Pharmaceutical Formulations & Drug Delivery

Hydrogels have aƩ racted research aƩ enƟ on for Ɵ ssue engineering. ThermosensiƟ ve amphiphilic block copolymers, polyethylene oxide-polypropylene oxide copolymers (Poloxamers or Pluronics, PPO-PEO-PPO), thanks to their ability to undergo thermal gelaƟ on, to their good tolerability, and low irritancy/

toxicity, have been used in the biomedical fi eld. These materials could be applied as drug/biomolecule carrier to protect them from a hosÆŸ le environment and modulaÆŸ ng delivery in response to temperature change. Hyaluronic acid (HA) is naturally occurring glycosaminoglycan, presents in mammalian connecÆŸ ve ÆŸ ssues. It has been demonstrated that HA promotes dermal regeneraÆŸ on and for this, it is widely used as dermal fi llers, as wound dressings and substrates for dermal engineering applicaÆŸ ons. It has to be

highlighted that infecÆŸ on is a crucial and generally unsolved issue in ÆŸ ssue regeneraÆŸ on. Therefore, materials containing anÆŸ microbial compounds, such as quaternary ammonium salts, TiO2, and, Ag nanoparÆŸ cles have been uÆŸ lized. Among these compounds, Ag NPs have shown the capability to inhibit or decline infecÆŸ ons. Various techniques, including chemical and physical approaches, have been developed to synthesis Ag NPs. Unfortunately, in the aforemenÆŸ oned approaches, organic passivators, toxic both for the environment and the human body, are used. Biosynthesis of NPs, by using microorganisms and plants,

has received considerable aƩ enƟ on due to the growing need to develop environmentally and non-toxic technologies. In this context, we propose novel and green nanocomposites injectable hydrogels based on HA, Pluronics, and AgNPs for Ɵ ssue regeneraƟ on and drug delivery applicaƟ ons.